WDR5 WIN site inhibitor C6 (WDR5-IN-4)

Chemical Structure : WDR5 WIN site inhibitor C6

CAS No.: 2407457-36-5

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货号: PC-36119Not For Human Use, Lab Use Only.

WDR5 inhibitor C6 (WDR5-IN-4) is a highly potent WDR5 WIN site inhibitor with Kd of 0.1 nM.

规格	价格	库存
5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

WDR5 inhibitor C6 (WDR5-IN-4) is a highly potent WDR5 WIN site inhibitor with Kd of 0.1 nM.
WDR5 inhibitor C6 inhibits cell lines and primary transformed cells carrying MLL1 rearrangements (MV4:11, IC50=3.2 uM), induces apoptosis and kills cells in a p53-dependent manner.
WDR5 inhibitor C6 rapidly displace WDR5 from chromatin and decrease the expression of associated genes, causing translational inhibition, nucleolar stress, and p53 induction.

物理化学性质&存储条件

分子量	498.383
分子式	C25H22Cl2FN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3,4-dichlorobenzyl)-3-(6-fluoro-2-methylpyridin-3-yl)-5-((2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl)methyl)benzamide

参考文献

1. Aho ER, et al. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.