WC-27 | Wee1 inhibitor | Probechem Biochemicals

Chemical Structure : WC-27

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WC-27 (WC27)

货号: PC-28612Not For Human Use, Lab Use Only.

WC-27 is a highly potent, selective serine/threonine kinase Wee1 inhibitor with IC50 of 2.11 nM, has high selectivity over PLK1 (IC50>1000 nM).

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生物&药学活性

WC-27 is a highly potent, selective serine/threonine kinase Wee1 inhibitor with IC50 of 2.11 nM, has high selectivity over PLK1 (IC50>1000 nM).
WC-27 displays potent antiproliferative activity against NCI-H1299 cell line with IC50 of 1.05 uM.
WC-27 arrests NCI-H1299 cells in S phase and induce apoptosis in a dose-dependent manner.

物理化学性质&存储条件

分子量	490.39
分子式	C22H25Cl2N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2,6-dichlorophenyl)-4-ethoxy-2-((1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidine-5-carboxamide

参考文献

1. Fei Chen, et al. Eur J Med Chem. 2026 Oct 7;321(Pt 2):119402.

WC-27 (WC27)

生物&药学活性

物理化学性质&存储条件

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WC-27 (WC27)

生物&药学活性

物理化学性质&存储条件

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