WAY 163909 | 5-HT2C agonist | Probechem Biochemicals

Chemical Structure : WAY 163909

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WAY 163909 (WAY163909;WAY-163909)

货号: PC-61117Not For Human Use, Lab Use Only.

WAY 163909 is a highly potent, subtype-selective agonist of 5-HT2C receptor with Ki of 10.5 nM, >20-fold selectivity over 5-HT2A and 5-HT2B receptor subtypes (IC50=212 and 485 nM, respectively).

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生物&药学活性

WAY 163909 is a highly potent, subtype-selective agonist of 5-HT2C receptor with Ki of 10.5 nM, >20-fold selectivity over 5-HT2A and 5-HT2B receptor subtypes (IC50=212 and 485 nM, respectively).
WAY 163909 stimulates the mobilization of intracellular calcium in CHO cells stably expressing the human 5-HT2C with EC50 of 8 nM.
WAY 163909 produces a dose-dependent reduction in food intake in rat (ED50=2.93 mg/kg), also exhibits preclinical antipsychotic-like activity in vivo.

物理化学性质&存储条件

分子量	214.31
分子式	C14H18N2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(11R,15R)-7,10-diazatetracyclo[8.5.1.0^{5,16}.0^{11,15}]hexadeca-1,3,5(16)-triene

参考文献

1. Dunlop J, et al. J Pharmacol Exp Ther. 2005 May;313(2):862-9.

2. Marquis KL, et al. J Pharmacol Exp Ther. 2007 Jan;320(1):486-96.

3. Rosenzweig-Lipson S, et al. Psychopharmacology (Berl). 2007 Jun;192(2):159-70.

4. Grauer SM, et al. Psychopharmacology (Berl). 2009 May;204(1):37-48.

WAY 163909 (WAY163909;WAY-163909)

生物&药学活性

物理化学性质&存储条件

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WAY 163909 (WAY163909;WAY-163909)

生物&药学活性

物理化学性质&存储条件

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