WAY-362692 |CAS:915763-27-8 Probechem Biochemicals

Chemical Structure : WAY-362692

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WAY-362692 (WAY362692)

货号: PC-63016Not For Human Use, Lab Use Only.

WAY-362692 is a small molecule inhibitor of the secreted frizzled-related protein sFRP-1 with IC50 of 20 nM in FP binding assay.

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生物&药学活性

WAY-362692 is a small molecule inhibitor of the secreted frizzled-related protein sFRP-1 with IC50 of 20 nM in FP binding assay.
WAY-362692 exhibits Wnt signaling inhibition in U2-OS cell lines with EC50 of 30 nM.
WAY-362692 increases total bone area (75%) relative to the vehicle control in an ex vivo mouse calvaria model for bone formation.

物理化学性质&存储条件

分子量	644.725
分子式	C28H35F3N4O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-N-(tert-Butyl)-2-{[4-({[5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)piperidin-1-yl]carbonyl}pyrrolidine-1-carboxamid

参考文献

1. Moore WJ, et al. J Med Chem. 2009 Jan 8;52(1):105-16.

WAY-362692 (WAY362692)

生物&药学活性

物理化学性质&存储条件

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WAY-362692 (WAY362692)

生物&药学活性

物理化学性质&存储条件

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