WAY-267464 | OXTR agonist | Probechem Biochemicals

Chemical Structure : WAY-267464

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WAY-267464 (WAY267464)

货号: PC-35701Not For Human Use, Lab Use Only.

WAY-267464 (WAY267464) is a potent, selective, non-peptide oxytocin receptor agonist with Ki of 58.4 nM, >100-fold selectivity over V1a, V2, V1b receptors.

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生物&药学活性

WAY-267464 (WAY267464) is a potent, selective, non-peptide oxytocin receptor agonist with Ki of 58.4 nM, >100-fold selectivity over V1a, V2, V1b receptors.
WAY-267464 exhibits an anxiolytic-like profile similar to oxytocin (OT), also significantly reverses disruption in prepulse inhibition of the acoustic startle reflex induced by either MK-801 or amphetamine in vivo.

物理化学性质&存储条件

分子量	654.593
分子式	C32H37Cl2N7O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3,5-Dihydroxy-benzyl)-piperazine-1-carboxylic acid 2-methyl-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide dihydrochloride

参考文献

1. Ring RH, et al. Neuropharmacology. 2010 Jan;58(1):69-77.

2. Hicks C, et al. J Neuroendocrinol. 2012 Jul;24(7):1012-29.

3. Hicks C, et al. Br J Pharmacol. 2014 Jun;171(11):2868-87.

4. Hicks C, et al. Psychopharmacology (Berl). 2015 Aug;232(15):2659-67.

WAY-267464 (WAY267464)

生物&药学活性

物理化学性质&存储条件

参考文献

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WAY-267464 (WAY267464)

生物&药学活性

物理化学性质&存储条件

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