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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Estrogen Receptor/ERR-WAY-200070
WAY-200070

Chemical Structure : WAY-200070

CAS No.: 440122-66-7

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WAY-200070 (WAY200070;WAY 200070)

货号: PC-42344Not For Human Use, Lab Use Only.

WAY-200070 is a potent, highly selective ERβ agonist with IC50 of 3 nM, displays 68-fold selectivity over ERα (IC50=260 nM).

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

WAY-200070 is a potent, highly selective ERβ agonist with IC50 of 3 nM, displays 68-fold selectivity over ERα (IC50=260 nM).
WAY-200070 induces galanin expression within gonadotropin hormone-releasing hormone-immunoreactive neurons in the female rat brain, causes and learn the socially acquired preferenc in mice.
WAY-200070 deonstrates the anxiolytic-like and antidepressant-like effects in vivo.

物理化学性质&存储条件

分子量 306.11152
分子式 C13H8BrNO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 31 mg/mL
Chemical Name/SMILES

5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)-

参考文献

1. Hughes ZA, et al. Neuropharmacology. 2008 Jun;54(7):1136-42.

2. Clipperton AE, et al. Neuropsychopharmacology. 2008 Sep;33(10):2362-75.

3. Malamas MS, et al. J Med Chem. 2004 Oct 7;47(21):5021-40.

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