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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-W1131
W1131

Chemical Structure : W1131

CAS No.: 2740522-79-4

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W1131 (W 1131)

货号: PC-38849Not For Human Use, Lab Use Only.

W1131 is a potent and selective STAT3 inhibitor with Kd of 7.55 uM in surface plasmon resonance (SPR) assays, inhibits STAT3 Tyr705 phosphorylation, triggers ferroptosis and possesses potent anti-tumor effects both in vitro and in vivo.

规格 价格 库存 数量
5 mg ￥2480 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

W1131 is a potent and selective STAT3 inhibitor with Kd of 7.55 uM in surface plasmon resonance (SPR) assays, inhibits STAT3 Tyr705 phosphorylation, triggers ferroptosis and possesses potent anti-tumor effects both in vitro and in vivo.
W1131 inhibited STAT3 tyrosine phosphorylation and dimerization, accumulation of nuclear pY705-STAT3, and transcriptional activity.
W1131 inhibited STAT3 Tyr705 phosphorylation in a time- and dose-dependent manner without obvious effect on the activation of STAT1 and STAT5, W1131 had no obvious effect on phospho-JAK2 or phospho-AKT levels.
W1131 strongly inhibited cell survival, migration, and invasion, W1131 (1 uM) triggers ferroptosis and inhibited GPX4, SLC7A11, and FTH1 expression in gastric cancer cells.
W1131 (3 mg/kg and 10 mg/kg, i.p.) induced ferroptosis and regressed tumor growth of gastric cancer in vivo.
W1131 also alleviated chemotherapy resistance (5-FU) in multiple models of gastric cancer.

物理化学性质&存储条件

分子量 429.436
分子式 C23H19N5O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Furancarboxamide, 5-nitro-N-[4-[7-(1,2,3,6-tetrahydro-4-pyridinyl)imidazo[1,2-a]pyridin-3-yl]phenyl]-

参考文献

1. Ouyang S, et al. Redox Biol. 2022 Jun;52:102317.

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