Vps34 inhibitor PIK-III |CAS:1383716-40-2 Probechem Biochemicals

Chemical Structure : Vps34 inhibitor PIK-III

CAS No.: 1383716-40-2

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Vps34 inhibitor PIK-III (PIK-III)

货号: PC-43213Not For Human Use, Lab Use Only.

Vps34 inhibitor PIK-III (PIK-III) is a potent, selective inhibitor of Vps34 with IC50 of 18 nM, shows >100-fold selectivity over other class I PI3Ks, PI4Kβ and mTOR.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

Vps34 inhibitor PIK-III (PIK-III) is a potent, selective inhibitor of Vps34 with IC50 of 18 nM, shows >100-fold selectivity over other class I PI3Ks, PI4Kβ and mTOR.
Vps34 inhibitor PIK-III inhibits the localization of GFP-FYVE in mammalian cells with IC50 of 55 nM, which is >10,000 times more potent than the non-selective VPS34 inhibitor 3-MA.
Vps34 inhibitor PIK-III robustly inhibits autophagy and LC3 lipidation, leads to the stabilization of autophagy substrates in mammalian cells.

物理化学性质&存储条件

分子量	319.3638
分子式	C17H17N7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	[4,5'-Bipyrimidine]-2,2'-diamine, 4'-(cyclopropylmethyl)-N2-4-pyridinyl-

参考文献

1. Dowdle WE, et al. Nat Cell Biol. 2014 Nov;16(11):1069-79.

2. Honda A, et al. ACS Med Chem Lett. 2015 Nov 13;7(1):72-6.

Vps34 inhibitor PIK-III (PIK-III)

生物&药学活性

物理化学性质&存储条件

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Vps34 inhibitor PIK-III (PIK-III)

生物&药学活性

物理化学性质&存储条件

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