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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HCV-Voxilaprevir
Voxilaprevir

Chemical Structure : Voxilaprevir

CAS No.: 1535212-07-7

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Voxilaprevir (GS-9857, GS9857)

货号: PC-61440Not For Human Use, Lab Use Only.

Voxilaprevir (GS-9857) is a potent HCV NS3/4A protease inhibitor that is used in combination with sofosbuvir and velpatasvir for treatment of HCV infection.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Voxilaprevir (GS-9857) is a potent HCV NS3/4A protease inhibitor that is used in combination with sofosbuvir and velpatasvir for treatment of HCV infection.

物理化学性质&存储条件

分子量 868.94
分子式 C40H52F4N6O9S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(33R,34S,35S,91R,92R,5S)-5-(tert-butyl)-N-((1R,2R)-2-(difluoromethyl)-1-(((1-methylcyclopropyl)sulfonyl)carbamoyl)cyclopropyl)-34-ethyl-14,14-difluoro-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-carboxamide

参考文献

1. Bourlière M, et al. N Engl J Med. 2017 Jun 1;376(22):2134-2146.

2. Gane EJ, et al. Gastroenterology. 2016 Nov;151(5):902-909.

3. Lawitz E, et al. Gastroenterology. 2016 Nov;151(5):893-901.e1.

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