Voruciclib (P1446A-05) | CDK9 inhibitor | Probechem Biochemicals

Chemical Structure : Voruciclib

CAS No.: 1000023-04-0

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Voruciclib (P1446A-05, P1446A)

货号: PC-61031Not For Human Use, Lab Use Only.

Voruciclib (P1446A-05) is a potent, selective and orally bioavailable CDK9 inhibitor with Ki of 0.63 nM and 1.68 nM for CDK9/cyclinT2 and CDK9/cyclinT1, respectively.

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10 mg	￥3980	In stock
25 mg	￥5980	In stock
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生物&药学活性

Voruciclib (P1446A-05) is a potent, selective and orally bioavailable CDK9 inhibitor with Ki of 0.63 nM and 1.68 nM for CDK9/cyclinT2 and CDK9/cyclinT1, respectively.
Voruciclib (P1446A-05) also inhibits CDK6/cyclin D1, CDK4/cyclin D1, CDK1/cyclin B and CDK1/cyclin A with Ki of 3-10 nM, shows weak activity against MAK and ICK (Ki>250 nM).
Voruciclib (P1446A-05) exhibits more selective target profile than flavopiridol, represses MCL-1 protein expression in preclinical models of DLBCL.
Voruciclib (P1446A-05) causes tumor cell apoptosis and tumor growth inhibition combined with venetoclax in vivo.

物理化学性质&存储条件

分子量	469.841
分子式	C22H19ClF3NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[2-Chloro-4-(trifluoromethyl)phenyl]-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-4H-1-benzopyran-4-one

参考文献

1. Dey J, et al. Sci Rep. 2017 Dec 21;7(1):18007.

Voruciclib (P1446A-05, P1446A)

生物&药学活性

物理化学性质&存储条件

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Voruciclib (P1446A-05, P1446A)

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