Vornorexant (TS-142) | Orexin Receptor inhibitor | Probechem Biochemicals

Chemical Structure : Vornorexant

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Vornorexant (TS-142, ORN0829)

货号: PC-38428Not For Human Use, Lab Use Only.

Vornorexant (TS-142, ORN0829) is a potent dual orexin 1 and 2 receptor antagonist with IC50 of 1.05 and 1.27 nM for hOX1R and hOX2R, resepctively.

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生物&药学活性

Vornorexant (TS-142, ORN0829) is a potent dual orexin 1 (OX1R) and 2 receptor (OX2R) antagonist with IC50 of 1.05 and 1.27 nM for hOX1R and hOX2R, resepctively.
Vornorexant (TS-142, ORN0829) exhibited potent sleep-promoting effects at a po dose of 1 mg/kg in a rat polysomnogram study.
Vornorexant (TS-142, ORN0829) is a viable candidate and is currently in clinical development for the treatment of insomnia.

物理化学性质&存储条件

分子量	447.474
分子式	C23H22FN7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[(2S)-2-[[3-(5-Fluoro-2-pyridinyl)-1H-pyrazol-1-yl]methyl]dihydro-2H-1,3-oxazin-3(4H)-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone

参考文献

1. Futamura A, et al. Bioorg Med Chem. 2020 Jul 1;28(13):115489.

2. Uchiyama M, et al. Psychopharmacology (Berl). 2022 Mar 17.

Vornorexant (TS-142, ORN0829)

生物&药学活性

物理化学性质&存储条件

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Vornorexant (TS-142, ORN0829)

生物&药学活性

物理化学性质&存储条件

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