Vormatrigine | Persistent INa inhibitor, NaV blocker | Probechem Biochemicals

Chemical Structure : Vormatrigine

CAS No.: 2392951-18-5

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Vormatrigine (PRAX-628, PRAX628)

货号: PC-25007Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock

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生物&药学活性

Vormatrigine (PRAX-628) is a potent and activity dependent inhibitor of persistent and peak sodium current (INa) with IC50 of 128 nM, a NaV blocker with greater potency and preference for persistent INa.
PRAX-628 inhibits ATX-II induced persistent INa expressed by multiple NaV isoforms and orthologs.
PRAX-628 inhibits persistent sodium current (INa) in neurons, a mechanism linked to epilepsy.
PRAX-628 exhibits fast apparent binding and moderate apparent unbinding compared to a panel of standard of NaV blockers.

物理化学性质&存储条件

分子量	406.29
分子式	C16H12F6N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(ethoxydifluoromethyl)-6-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyridine

参考文献

1. Kristopher M. Kahlig, et al. PRAX-628: A Novel Sodium Channel Blocker with Greater Potency and Activity Dependence Compared to Standard of Care.

2. Patent WO2019232209 A1 2019-12-05.

Vormatrigine (PRAX-628, PRAX628)

生物&药学活性

物理化学性质&存储条件

参考文献

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Vormatrigine (PRAX-628, PRAX628)

生物&药学活性

物理化学性质&存储条件

参考文献

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