Vorapaxar (SCH 530348) | PAR1 antagonist | Probechem Biochemicals

Chemical Structure : Vorapaxar

CAS No.: 618385-01-6

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Vorapaxar (SCH530348, SCH-530348, SCH 530348)

货号: PC-42330Not For Human Use, Lab Use Only.

Vorapaxar (SCH 530348) is a potent, selective and orally active thrombin receptor PAR-1 antagonist with Ki of 8.1 nM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg	￥5580	In stock
250 mg		Get quote

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生物&药学活性

Vorapaxar (SCH 530348) is a potent, selective and orally active thrombin receptor PAR-1 antagonist with Ki of 8.1 nM.
Vorapaxar (SCH 530348) displays no activity against e PAR-2, PAR-3 and PAR-4, and no CYP450 enzyme inhibition potential.
Vorapaxar (SCH 530348) inhibits thrombin (10 nM) induced human platelet aggregation with IC50 of 47 nM.
Vorapaxar (SCH 530348) inhibits haTRAP-induced platelet aggregation in vivo.

物理化学性质&存储条件

分子量	492.5817
分子式	C29H33FN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	Carbamic acid, N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester

参考文献

1. Chackalamannil S, et al. J Med Chem. 2008 Jun 12;51(11):3061-4.

2. Chintala M, et al. J Pharmacol Sci. 2008 Dec;108(4):433-8.

3. Goto S, et al. J Atheroscler Thromb. 2010 Feb 26;17(2):156-64.

4. Becker RC, et al. Lancet. 2009 Mar 14;373(9667):919-28.

Vorapaxar (SCH530348, SCH-530348, SCH 530348)

生物&药学活性

物理化学性质&存储条件

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Vorapaxar (SCH530348, SCH-530348, SCH 530348)

生物&药学活性

物理化学性质&存储条件

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