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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Farnesoid X Receptor (FXR)-Vonafexor
Vonafexor

Chemical Structure : Vonafexor

CAS No.: 1192171-69-9

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Vonafexor (EYP001, EYP-001)

货号: PC-28796Not For Human Use, Lab Use Only.

Vonafexor (EYP001) is a synthetic, orally active, non-steroidal, non-bile acid agonist of arnesoid X receptor (FXR), also inhibits HBV transcriptional activity, blocks c-Rel nuclear entry in MDSCs, induces sublethal damage of HBV-positive liver cancer cells.

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50 mg ￥1480 In stock
100 mg ￥2480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Vonafexor (EYP001) is a synthetic, orally active, non-steroidal, non-bile acid agonist of farnesoid X receptor (FXR), also inhibits HBV transcriptional activity, blocks c-Rel nuclear entry in MDSCs, induces sublethal damage of HBV-positive liver cancer cells.

物理化学性质&存储条件

分子量 489.75
分子式 C19H15Cl3N2O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-Chloro-5-(4-((2,6-dichlorophenyl)sulfonyl)piperazin-1-yl)benzofuran-2-carboxylic acid

参考文献

1. Ratziu V, et al. J Hepatol. 2023 Mar;78(3):479-492.

2. Pan B, et al. Br J Cancer. 2025 Sep;133(5):697-708.

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