Chemical Structure : Vofopitant dihydrochloride
CAS No.:
168266-51-1
Vofopitant dihydrochloride
(GR 205171A)
货号: PC-23398Not For Human Use, Lab Use Only.
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively.
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纯度 & COA & 质检文件 纯度:
>98% (HPLC)
生物&药学活性
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively.
Vofopitant prevents vagal stimulation-induced retching but not neuronal transmission from emetic vagal afferents to solitary nucleus neurons in dogs.
Vofopitant exhibits an acute response to cisplatin but does not vomit during the delayed phase.
物理化学性质&存储条件
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分子量
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505.37
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分子式
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C21H25Cl2F3N6O
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外观性状
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Solid
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CAS No.
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储存条件
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- 固体粉末
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-20°C 12 个月; 4°C 6 个月
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- 配置液
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-80°C 6 个月; -20°C 6 个月
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2S,3S)-N-(2-Methoxy-5-(5-(trifluoromethyl)-1H-tetrazol-1-yl)benzyl)-2-phenylpiperidin-3-amine dihydrochloride
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参考文献
1. Gardner CJ, et al. Regul Pept. 1996 Aug 27;65(1):45-53.
2. Gobert A, et al. Neuropsychopharmacology. 2009 Mar;34(4):1039-56.
3. Heldt SA, et al. Behav Pharmacol. 2009 Oct;20(7):584-95.
4. Malik NM, et al. Eur J Pharmacol. 2007 Jan 26;555(2-3):164-73.
