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首页-抗体和重组蛋白-Biosimilar Antibody-Vixarelimab
Vixarelimab

Chemical Structure : Vixarelimab

CAS No.: 2243320-83-2

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Vixarelimab (KPL 716)

货号: PC-38872Not For Human Use, Lab Use Only.

Vixarelimab (KPL-716) is a fully-human monoclonal antibody that targets oncostatin M receptor beta (OSMRβ), which mediates signaling of interleukin-31 (IL-31) and oncostatin M (OSM), two key cytokines implicated in pruritus, inflammation and fibrosis.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Vixarelimab (KPL-716) is a fully-human monoclonal antibody that targets oncostatin M receptor beta (OSMRβ), which mediates signaling of interleukin-31 (IL-31) and oncostatin M (OSM), two key cytokines implicated in pruritus, inflammation and fibrosis.
Vixarelimab (KPL-716) significantly attenuated MCP-1 response to OSM and OSM + IL-4 in human epidermal keratinocytes and human dermal fibroblasts, but not anti-IL-31Rα.

Isotype: IgG4-G1-lambda2.

Anti-[human OSMR (oncostatin M receptor, OSMRB, OSMRbeta)], human monoclonal antibody.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Richards CD, et al. Acta Derm Venereol. 2020 Jul 2;100(14):adv00197.

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