Virapinib

Chemical Structure : Virapinib

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货号: PC-22547Not For Human Use, Lab Use Only.

Virapinib is a specific inhibitor of macropinocytosis with antiviral activity, limits viral entry by macropinocytosis for several viruses including SARS-CoV-2.

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生物&药学活性

Virapinib is a specific inhibitor of macropinocytosis with antiviral activity, limits viral entry by macropinocytosis for several viruses including SARS-CoV-2.
Virapinib presented a dose-dependent effect in limiting SARS-CoV-2 infection in Vero E6 cells and had no detectable toxic or
cytostatic effects.
Virapinib exhibits a dose-dependent effect in inhibiting the infection by SARS-CoV-2 and no detectable toxicity in A549ACE2 cells.
Virapinib showed anti-infective activity against all variants in both Vero E6 and A549ACE2 cells, including Alpha (B.1.1.7), Delta (B.1.617.2), and Omicron sub-lineages (e.g. BA.1).
Virapinib efficiently reduced SARS-CoV-2 infectivity in a well-established liver spheroid model of extrapulmonary SARS-CoV-2 infection.
Virapinib selectively inhibited the macropinocytic route, while not having a detectable impact on single-particle entry, the cell membrane or the integrity of intracellular organelles.
Virapinib broadly inhibits infection by Mpox, TBEV and Ebola viruses.

物理化学性质&存储条件

分子量	448.62
分子式	C26H36N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-(7-methyl-4-(methylamino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)pyrrolidin-1-yl)(4-(4-methylpiperidin-1-yl)phenyl)methanone

参考文献

1. Porebski B, et al. Mol Ther. 2024 Jul 1:S1525-0016(24)00455-6.

Virapinib

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Virapinib

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