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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-Vinpocetine
Vinpocetine

Chemical Structure : Vinpocetine

CAS No.: 42971-09-5

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Vinpocetine (Ethyl apovincaminate)

货号: PC-43473Not For Human Use, Lab Use Only.

Vinpocetine (Ethyl apovincaminate) is a synthetic derivative of the vinca alkaloid vincamine, selectively inhibits PDE1 in isolated rabbit aorta with IC50 of 21 uM.

规格 价格 库存 数量
100 mg ￥780 In stock
200 mg ￥1180 In stock
1 g ￥110 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Vinpocetine (Ethyl apovincaminate) is a synthetic derivative of the vinca alkaloid vincamine, selectively inhibits PDE1 in isolated rabbit aorta with IC50 of 21 uM.
Vinpocetine inhibits IKK preventing IκB degradation and the following translocation of NF-κB to the cell nucleus.
Vinpocetine potently inhibits TNF-alpha- or LPS-induced up-regulation of proinflammatory mediators, including TNF-alpha, IL-1beta, and macrophage inflammatory protein-2, and decreases interstitial infiltration of polymorphonuclear leukocytes in mouse model of lung inflammation.
Vinpocetine demonstrates cerebral blood-flow enhancing and neuroprotective effects in vivo.

物理化学性质&存储条件

分子量 350.45
分子式 C22H26N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: < 1 mg/mL
Chemical Name/SMILES

Eburnamenine-14-carboxylic acid, ethyl ester, (3α,16α)-

参考文献

1. Souness JE, et al. Br J Pharmacol. 1989 Nov;98(3):725-34.

2. Tomkinson A, et al. Br J Pharmacol. 1996 Aug;118(8):2131-9.

3. Loughney K, et al. J Biol Chem. 1996 Jan 12;271(2):796-806.

4. Jeon KI, et al. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9795-800.

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