Vinorelbine ditartrate | Tubulin inhibitor | Probechem Biochemicals

Chemical Structure : Vinorelbine ditartrate

CAS No.: 125317-39-7

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Vinorelbine ditartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate)

货号: PC-42867Not For Human Use, Lab Use Only.

Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM.

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50 mg	￥1480	In stock
100 mg	￥2380	In stock
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生物&药学活性

Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM.
Vinorelbine induces Hela mitotic block at the metaphase/anaphase transition with IC50 of 3.8 nM, blocks cells exhibited aberrant spindles, consistent with induction of block by suppression of microtubule dynamics.

物理化学性质&存储条件

分子量	1079.106
分子式	C53H66N4O20
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 46 mg/mL
Chemical Name/SMILES	Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-, (2R,3R)-2,3-dih

参考文献

1. Rahmani R, et al. Cancer Chemother Pharmacol. 1986;16(3):223-8.

2. Ngan VK, et al. Mol Pharmacol. 2001 Jul;60(1):225-32.

3. Monnet I, et al. Eur J Cancer. 1991;27(12):1716-7.

4. Rahmani R, et al. Cancer Res. 1984 Dec;44(12 Pt 1):5609-13.

Vinorelbine ditartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate)

生物&药学活性

物理化学性质&存储条件

参考文献

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Vinorelbine ditartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate)

生物&药学活性

物理化学性质&存储条件

参考文献

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