VinSpinIn |CAS 2380021-98-5 Probechem Biochemicals

Chemical Structure : VinSpinIn

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VinSpinIn

货号: PC-35846Not For Human Use, Lab Use Only.

VinSpinIn is a potent, cell active chemical probe for the Spin family protein with Kd of 10-130 nM for across the family, displays >300-fold selectivity over a panel of methyltransferases.

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生物&药学活性

VinSpinIn is a potent, cell active chemical probe for the Spin family protein with Kd of 10-130 nM for across the family (SPIN1, Kd=9.9 nM), displays >300-fold selectivity over a panel of methyltransferases.
VinSpinIn demonstrates dose dependant inhibition of the Spin1-H3 interaction in a NanoBRET cellular target engagement assay.

物理化学性质&存储条件

分子量	738.978
分子式	C42H58N8O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(2-((2-(3-((2-amino-5-(cyclopropylmethoxy)-3,3-dimethyl-3H-indol-6-yl)oxy)propyl)isoindolin-5-yl)oxy)ethyl)-1H-1,2,3-triazol-1-yl)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethan-1-one

参考文献

1 Fagan V, et al. J Med Chem. 2019 Oct 24;62(20):9008-9025.

VinSpinIn

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物理化学性质&存储条件

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VinSpinIn

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