Vilazodone | 5-HT1A agonist, SSRI | Probechem Biochemicals

Chemical Structure : Vilazodone

CAS No.: 163521-12-8

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Vilazodone (EMD68843, SB659746A)

货号: PC-23306Not For Human Use, Lab Use Only.

Vilazodone (EMD68843, SB659746A) is a potent, dual 5-HT1A agonist and serotonin reuptake inhibitor (SSRI) with IC50 of 0.2 nM at the human 5-HT1A receptor and 0.5 nM for the SERT.

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10 mg	￥1480	In stock
25 mg	￥2580	In stock
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生物&药学活性

Vilazodone (EMD68843, SB659746A) is a potent, dual 5-HT1A agonist and serotonin reuptake inhibitor (SSRI) with IC50 of 0.2 nM at the human 5-HT1A receptor and 0.5 nM for the SERT.
Vilazodone (EMD 68843; SB 659746A) binds to the high agonist affinity state of human 5-HT1A receptors, and displays high affinity (pKi≥9.3) for human recombinant and rat, guinea pig, mouse, and marmoset native tissue 5-HT1A receptors.
Vilazodone (EMD 68843; SB 659746A) is a potent 5‐HT reuptake inhibitor in rat and guinea pig cortex, inhibits [3H]5‐HT uptake with a pIC50 of 8.8 in LLCPK cells expressing human SERT.
Vilazodone (3 mg/kg ; i.p,; single dose) produces increases in extracellular levels of 5‐HT in both the frontal cortex (FC) and ventral hippocampus (vHipp) of rats.

物理化学性质&存储条件

分子量	441.54
分子式	C26H27N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide

参考文献

1. Hughes ZA, et al. Eur J Pharmacol. 2005 Mar 7;510(1-2):49-57.

2. Heinrich T, et al. J Med Chem. 2004 Sep 9;47(19):4684-92.

3. Heinrich T, et al. Bioorg Med Chem. 2004 Sep 15;12(18):4843-52.

Vilazodone (EMD68843, SB659746A)

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Vilazodone (EMD68843, SB659746A)

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物理化学性质&存储条件

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