Vestipitant (GW597599) mesylate | NK1 receptor antagonist

Chemical Structure : Vestipitant mesylate

加入收藏

Vestipitant mesylate (GW597599, GW 597588B)

货号: PC-61579Not For Human Use, Lab Use Only.

Vestipitant (GW597599) mesylate is a potent, selective, orally active NK1 receptor antagonist with pKi of 9.65.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Vestipitant (GW597599) mesylate is a potent, selective, orally active NK1 receptor antagonist with pKi of 9.65.
Vestipitant (GW597599) potently blocks Substance P-mediated phosphorylation of ERK.
Vestipitant (GW597599) attenuates fear-induced foot-tapping in gerbils, separation-induced distress-vocalizations in guinea pigs, marble-burying behaviour in mice, and displayes anxiolytic actions in rats.

物理化学性质&存储条件

分子量	587.554
分子式	C24H28F7N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperazine-1-carboxamide mesylate

参考文献

1. Di Fabio R, et al. J Med Chem. 2009 May 28;52(10):3238-47.

2. Brocco M, et al. Eur Neuropsychopharmacol. 2008 Oct;18(10):729-50.

3. Ratti E, et al. Sleep. 2013 Dec 1;36(12):1823-30.

4. Poma SZ, et al. J Psychopharmacol. 2014 May;28(5):491-7.

Vestipitant mesylate (GW597599, GW 597588B)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Vestipitant mesylate (GW597599, GW 597588B)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.