Verucopeptin | v-ATPase inhibitor | Probechem Biochemicals

Chemical Structure : Verucopeptin

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Verucopeptin (BS-1152)

货号: PC-72574Not For Human Use, Lab Use Only.

Verucopeptin (BS-1152) is a cyclodepsipeptide with notable antitumor potency, directly taregts ATP6V1G, a subunit of the vacuolar H+-ATPase (v-ATPase).

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100 ug		Get quote
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500 ug		Get quote
1 mg		Get quote

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生物&药学活性

Verucopeptin (BS-1152) is a cyclodepsipeptide with notable antitumor potency, directly taregts ATP6V1G, a subunit of the vacuolar H+-ATPase (v-ATPase).
Verucopeptin exhibited strong inhibition of both v-ATPase activity and mTORC1 signaling, leading to substantial pharmacological efficacy against SGC7901/VCR cell proliferation.
Verucopeptin inhibited tumor growth SGC7901/VCR xenograft model (1 mg/kg) without significant body weight loss or gross signs of toxicity.
Verucopeptin showed excellent antitumor activity against K562R cells with IC50 of 388 nM, showed substantial inhibition of v-ATPase activity at 10 nM in vitro.

物理化学性质&存储条件

分子量	896.093
分子式	C43H73N7O13
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-{Aaa}-G-{Sar}-G-{Sar} Lactone:(Leu1-Sar6)

参考文献

1. Takahashi N, et al. Chem Commun (Camb). 2019 Oct 1;55(79):11956-11959.

2. Wang Y, et al. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8.

3. Sugawara K, et al. J Antibiot (Tokyo). 1993 Jun;46(6):928-35.

Verucopeptin (BS-1152)

生物&药学活性

物理化学性质&存储条件

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Verucopeptin (BS-1152)

生物&药学活性

物理化学性质&存储条件

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