Verubecestat (MK-8931) | BACE inhibitor | Probechem Biochemicals

Chemical Structure : Verubecestat

CAS No.: 1286770-55-5

加入收藏

Verubecestat (MK-8931, MK8931)

货号: PC-45073Not For Human Use, Lab Use Only.

Verubecestat (MK-8931) is a potent, selective, structurally unique BACE inhibitor with Ki of 2.2 nM and 0.38 nM for BACE1 and BACE2, respectively.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2280	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Verubecestat (MK-8931) is a potent, selective, structurally unique BACE inhibitor with Ki of 2.2 nM and 0.38 nM for BACE1 and BACE2, respectively.
Verubecestat (MK-8931) displays high selectivity for BACE1 over other key aspartyl proteases, notably cathepsin D.
Verubecestat (MK-8931) reduces plasma, cerebrospinal fluid (CSF), and brain concentrations of Aβ40, Aβ42, and sAPPβ.
Verubecestat (MK-8931) is well tolerated and produces reductions in Aβ40, Aβ42, and sAPPβ in the CSF of both healthy human subjects and AD patients in clinical evaluation.

物理化学性质&存储条件

分子量	409.4104
分子式	C17H17F2N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 35 mg/mL
Chemical Name/SMILES	2-Pyridinecarboxamide, N-[3-[(5R)-3-amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-

参考文献

1. Kennedy ME,, et al. Sci Transl Med. 2016 Nov 2;8(363):363ra150.

2. Scott JD, et al. J Med Chem. 2016 Dec 8;59(23):10435-10450.

3. Villarreal S, et al. J Alzheimers Dis. 2017;59(4):1393-1413.

Verubecestat (MK-8931, MK8931)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Verubecestat (MK-8931, MK8931)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.