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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-ROCK-Verosudil
Verosudil

Chemical Structure : Verosudil

CAS No.: 1414854-42-4

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Verosudil (AR-12286, AR12286)

货号: PC-62715Not For Human Use, Lab Use Only.

Verosudil (AR-12286) is a potent ROCK inhibitor with Ki of 2 nM for both ROCK1 and ROCK2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Verosudil (AR-12286) is a potent ROCK inhibitor with Ki of 2 nM for both ROCK1 and ROCK2.
Verosudil (AR-12286) effectively lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork in animal models.

物理化学性质&存储条件

分子量 327.402
分子式 C17H17N3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(dimethylamino)-N-(1-oxo- 1,2-dihydroisoquinolin-6-yl)-2-(thiophen-3-yl)acetamide

参考文献

1. Sturdivant JM, et al. Bioorg Med Chem Lett. 2016 May 15;26(10):2475-80.

2. Kopczynski C, et al. Br J Ophthalmol. 2013 May;97(5):567-72.

3. Williams RD, et al. Am J Ophthalmol. 2011 Nov;152(5):834-41.e1.

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