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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-URAT1-Verinurad
Verinurad

Chemical Structure : Verinurad

CAS No.: 1352792-74-5

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Verinurad (RDEA-3170, RDEA3170)

货号: PC-45065Not For Human Use, Lab Use Only.

Verinurad (RDEA3170) is a highly potent and specific URAT1 inhibitor with IC50 of 25 nM.

规格 价格 库存 数量
10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2580 In stock
100 mg ￥4280 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Verinurad (RDEA3170) is a highly potent and specific URAT1 inhibitor with IC50 of 25 nM.
Verinurad (RDEA3170) displays 200-fold lower affinity for the related URAT1 homologs OAT4 and OAT1.
Verinurad (RDEA3170) reduces the sUA by up to 60% with a single 40 mg dose in healthy human volunteers, and increases the FEUA in a dose-dependent manner with EC50 of 22 nM.
Verinurad (RDEA3170) shows pptential for the treatment of gout and asymptomatic hyperuricemia.

物理化学性质&存储条件

分子量 348.4182
分子式 C20H16N2O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Propanoic acid, 2-[[3-(4-cyano-1-naphthalenyl)-4-pyridinyl]thio]-2-methyl-

参考文献

1. Tan PK, et al. Sci Rep. 2017 Apr 6;7(1):665.

2. Shen Z, et al. Drug Des Devel Ther. 2017 Jul 7;11:2077-2086.

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