Vericiguat |CAS:1350653-20-1 Probechem Biochemicals

Chemical Structure : Vericiguat

CAS No.: 1350653-20-1

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Vericiguat (BAY1021189, BAY-1021189)

货号: PC-61605Not For Human Use, Lab Use Only.

Vericiguat (BAY 1021189) is a novel potent, selective, orally available soluble guanylate cyclase (sGC) stimulator (MEC=0.3 uM), stimulating sGC NO-independently and in synergy with NO.

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5 mg	￥880	In stock
10 mg	￥1380	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Vericiguat (BAY 1021189) is a novel potent, selective, orally available soluble guanylate cyclase (sGC) stimulator (MEC=0.3 uM), stimulating sGC NO-independently and in synergy with NO.
Vericiguat (BAY 1021189) inhibits the U46619-induced contractions of porcine coronary artery rings with IC50 of 956 nM.
Vericiguat (BAY 1021189) reduces the coronary perfusion pressure in rat heart Langendorff preparations with no effect on heart rate, left ventricular diastolic pressure, and contractility.

物理化学性质&存储条件

分子量	426.388
分子式	C19H16F2N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl N-[4,6-diamino-2-[5-fluoro-1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate

参考文献

1. Follmann M, et al. J Med Chem. 2017 Jun 22;60(12):5146-5161.

Vericiguat (BAY1021189, BAY-1021189)

生物&药学活性

物理化学性质&存储条件

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Vericiguat (BAY1021189, BAY-1021189)

生物&药学活性

物理化学性质&存储条件

参考文献

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