Verdiperstat | MPO inhibitor | Probechem Biochemicals

Chemical Structure : Verdiperstat

CAS No.: 890655-80-8

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Verdiperstat (AZD-3241, AZD3241)

货号: PC-63145Not For Human Use, Lab Use Only.

Verdiperstat (AZD3241) is a potent, selective, reversible, orally active myeloperoxidase (MPO) inhibitor with IC50 of 630 nM, >14-fold selectivity over thyroid peroxidase (TPO).

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10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3480	In stock
100 mg	￥5580	In stock
250 mg		Get quote

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生物&药学活性

Verdiperstat (AZD3241) is a potent, selective, reversible, orally active myeloperoxidase (MPO) inhibitor with IC50 of 630 nM, >14-fold selectivity over thyroid peroxidase (TPO).
Verdiperstat (AZD3241) inhibits PMA stimulate neutrophils and zymosan stimulated whole blood with IC50 of 80 nM.
Verdiperstat (AZD3241) efficiently inhibits MPO activity in vivo during acute peritonitis in rats and has consistently shown neuroprotective efficacy in MPTP-lesioned mice, a model of Parkinson’s Disease.
Verdiperstat (AZD3241) also demonstrates significant neuroprotection in MSA mouse model.

物理化学性质&存储条件

分子量	253.32
分子式	C11H15N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[2-(propan-2-yloxy)ethyl]-2-sulfanylidene-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

参考文献

1. Jucaite A, et al. Brain. 2015 Sep;138(Pt 9):2687-700.

2. Kaindlstorfer C, et al. Neurotox Res. 2015 Oct;28(3):185-94.

Verdiperstat (AZD-3241, AZD3241)

生物&药学活性

物理化学性质&存储条件

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Verdiperstat (AZD-3241, AZD3241)

生物&药学活性

物理化学性质&存储条件

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