Vercirnon (GSK1605786, CCX282-B) | CCR9 inhibitor | Probechem Biochemicals

Chemical Structure : Vercirnon

CAS No.: 698394-73-9

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Vercirnon (GSK1605786, CCX282-B, Traficet-EN)

货号: PC-73249Not For Human Use, Lab Use Only.

Vercirnon (GSK1605786, CCX282-B) is a potent, selective, orally bioavailable antagonist of CCR9, inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 of 5.4 and 3.4 nM, respectively.

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5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

Vercirnon (GSK1605786, CCX282-B) is a potent, selective, orally bioavailable antagonist of CCR9, inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 of 5.4 and 3.4 nM, respectively.
Vercirnon (GSK1605786, CCX282-B) displays high selectivity for CCR9 over CCR1-12 and CX3CR1-7 (IC50>10 uM).
Vercirnon (GSK1605786, CCX282-B) is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively.
CCX282-B also inhibited mouse and rat CCR9-mediated chemotaxis.
Inhibition of CCR9 with CCX282-B results in normalization of Crohn's disease such as histopathology associated with the TNF(ΔARE) mice.

物理化学性质&存储条件

分子量	444.93
分子式	C22H21ClN2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-((4-(tert-Butyl)phenyl)sulfonamido)-5-chlorobenzoyl)pyridine 1-oxide

参考文献

1. Walters MJ, et al. J Pharmacol Exp Ther. 2010 Oct;335(1):61-9.

2. Keshav S, et al. PLoS One. 2013;8(3):e60094.

Vercirnon (GSK1605786, CCX282-B, Traficet-EN)

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Vercirnon (GSK1605786, CCX282-B, Traficet-EN)

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物理化学性质&存储条件

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