Venadaparib (IDX-1197) | PARP inhibitor | Probechem Biochemicals

Chemical Structure : Venadaparib

CAS No.: 1681017-83-3

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Venadaparib (IDX-1197, IDX1197)

货号: PC-38102Not For Human Use, Lab Use Only.

Venadaparib (IDX-1197) is a potent, selective PARP inhibitor with IC50 of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively.

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10 mg	￥1580	In stock
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生物&药学活性

Venadaparib (IDX-1197) is a potent, selective PARP inhibitor with IC50 of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively.
IDX-1197 does not inhibits PARP5A (Tankyrase-1, IC50>10 uM), which belongs to the PARP family.
IDX-1197 significantly inhibited PARP1-mediated PAR expression in DNA damage-induced Hela cells.
IDX-1197 exhibits potent tumor growth inhibition in germline BRCA1-mutated ovarian cancer PDX model.
IDX-1197 shows improved antitumor activity against breast cancer PDX models, which included both germline BRCA-mutated and non-germline BRCA-mutated models, compared with olaparib and/or niraparib.

物理化学性质&存储条件

分子量	406.461
分子式	C23H23FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-(3-((cyclopropylamino)methyl)azetidine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one

参考文献

1. Myongjae Lee, et al. Abstract A106: Development of IDX-1197, a novel, selective, and highly potent PARP inhibitor. American Association for Cancer Research, 2018.

Venadaparib (IDX-1197, IDX1197)

生物&药学活性

物理化学性质&存储条件

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Venadaparib (IDX-1197, IDX1197)

生物&药学活性

物理化学性质&存储条件

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