Vedroprevir | HCV NS3/4A inhibitor | Probechem Biochemicals

Chemical Structure : Vedroprevir

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Vedroprevir (GS9451, GS-9451)

货号: PC-63007Not For Human Use, Lab Use Only.

Vedroprevir (GS-9451) is a potent HCV NS3/4A protease inhibitor with Ki of 0.41 nM, inhibits HCV GT-1b NS3/4A with IC50 of 3.2 nM in enzymatic assays.

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生物&药学活性

Vedroprevir (GS-9451) is a potent HCV NS3/4A protease inhibitor with Ki of 0.41 nM, inhibits HCV GT-1b NS3/4A with IC50 of 3.2 nM in enzymatic assays.
Vedroprevir (GS-9451) exhibits low toxicity and high selectivity over mammalian proteases.

物理化学性质&存储条件

分子量	910.525
分子式	C45H60ClN7O9S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2R)-1-((2S)-1-((S)-2-(((((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)carbonyl)amino)-3,3-dimethylbutanoyl)-4-((8-chloro-2-(2-(isopropylamino)thiazol-4-yl)-7-(2-morpholinoethoxy)quinolin-4-yl)oxy)pyrrolidine-2-carboxamido)-2-ethylcyclopropane-1-carboxylic

参考文献

1. Sheng XC, et al. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2629-34.

2. Dvory-Sobol H, et al. Antimicrob Agents Chemother. 2012 Oct;56(10):5289-95.

3. Yang H, et al. Antimicrob Agents Chemother. 2014;58(2):647-53.

Vedroprevir (GS9451, GS-9451)

生物&药学活性

物理化学性质&存储条件

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Vedroprevir (GS9451, GS-9451)

生物&药学活性

物理化学性质&存储条件

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