Vebicorvir (ABI-H0731)

Chemical Structure : Vebicorvir

CAS No.: 2090064-66-5

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货号: PC-49567Not For Human Use, Lab Use Only.

Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor, exhibits selective inhibition of HBV DNA replication with EC50 from 173 nM to 307 nM.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor, exhibits selective inhibition of HBV DNA replication with EC50 from 173 nM to 307 nM.
Vebicorvir (ABI-H0731) ABI-H0731 suppressed covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s from 1.84 μM to 7.3 μM.
Vebicorvir (ABI-H0731) modulates the function of HBV core protein by promoting the assembly of aberrant capsids, blocking the encapsidation of pgRNA, and inhibiting the subsequent replication of HBV DNA, which ultimately leads to the inhibition of the production of mature viral particles.
Vebicorvir (ABI-H0731) showed broad-spectrum activity against genotypes A, B, C, and D with EC50 values from 86 to 142 nM.
Vebicorvir (ABI-H0731) exhibits pangenotypic activity and is additive to moderately synergistic when combined with NRTI entecavir (ETV).

物理化学性质&存储条件

分子量	467.437
分子式	C19H12F3N3O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	11-oxo-N-((2-(trifluoromethyl)thiazol-5-yl)methyl)-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide 5,5-dioxide

参考文献

1. Huang Q, et al. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01463-20.