Vanoxerine (GBR-12909, I-893, Boxeprazine) | Dopamine transport inhibitor

Chemical Structure : Vanoxerine

CAS No.: 67469-69-6

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Vanoxerine (Boxeprazine, GBR-12909, GBR12909, I893, I-893)

货号: PC-43400Not For Human Use, Lab Use Only.

Vanoxerine (GBR-12909, I-893, Boxeprazine) is a highly potent inhibitor of dopamine uptake in vitro in tissue slices obtained from rat neostriatum with IC50 of 40-50 nM, also inhibits norepinephrine uptake with IC50 of 560-2600 nM.

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25 mg	￥980	In stock
50 mg	￥1580	In stock
100 mg	￥2580	In stock
250 mg		Get quote

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生物&药学活性

Vanoxerine (GBR-12909, I-893, Boxeprazine) is a highly potent inhibitor of dopamine uptake in vitro in tissue slices obtained from rat neostriatum with IC50 of 40-50 nM, also inhibits norepinephrine uptake with IC50 of 560-2600 nM.
Vanoxerine also is a potent hK(v)11.1 blocker, and at submicromolar concentrations.
Vanoxerine blocks Ca and Na currents in a strongly frequency-dependent manner possesses anticonvulsant activity in zebrafish and rodent models of generalized epilepsy but with cardiac ion channel effects.
Vanoxerine also is a cancer-specific downregulator of G9a expression, suppresses cancer stem cell functions in colon tumors.

物理化学性质&存储条件

分子量	450.5633
分子式	C28H32F2N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Piperazine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)-

参考文献

1. Teicher MH, et al. Brain Res. 1986 Nov;395(1):124-8.

2. Heikkila RE, et al. Eur J Pharmacol. 1984 Aug 17;103(3-4):241-8.

3. Lacerda AE, et al. J Cardiovasc Electrophysiol. 2010 Mar;21(3):301-10.

4. Goldsmith P, et al. Pharmacology. 2007;79(4):250-8.

Vanoxerine (Boxeprazine, GBR-12909, GBR12909, I893, I-893)

生物&药学活性

物理化学性质&存储条件

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Vanoxerine (Boxeprazine, GBR-12909, GBR12909, I893, I-893)

生物&药学活性

物理化学性质&存储条件

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