Vanin-1 inhibitor | Vanin-1 inhibitor | Probechem Biochemicals

Chemical Structure : Vanin-1 inhibitor 2

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Vanin-1 inhibitor 2 (Vanin-1-IN-2)

货号: PC-72661Not For Human Use, Lab Use Only.

Vanin-1 inhibitor 2 is a potent, selective, oral Vanin-1 inhibitor with IC50 of 3.4 and 1.5 nM for human and mouse Vanin-1, respectively.

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生物&药学活性

Vanin-1 inhibitor 2 is a potent, selective, oral Vanin-1 inhibitor with IC50 of 3.4 and 1.5 nM for human and mouse Vanin-1, respectively.
Vanin-1 inhibitor (Vanin-1-IN-2) displays 1,000-fold selectivity against human biotinidase (IC50=8.3 uM).
Vanin-1 inhibitor (Vanin-1-IN-2) slightly ameliorates redox homeostasis gene expression in IRI kidneys but fails to reduce overall oxidative stress level and kidney injury markers.
Vanin-1 inhibitor (Vanin-1-IN-2) is insufficient to restore kidney function in an alport syndrome mouse model involving tubular protein overload.

物理化学性质&存储条件

分子量	342.362
分子式	C19H14N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-((1-(pyrimidin-5-yl)cyclopropyl)amino)pyrimidine-5-carbonyl)benzonitrile

参考文献

1. Unterschemmann K, et al. Am J Physiol Renal Physiol. 2021 Jan 1;320(1):F61-F73.

Vanin-1 inhibitor 2 (Vanin-1-IN-2)

生物&药学活性

物理化学性质&存储条件

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Vanin-1 inhibitor 2 (Vanin-1-IN-2)

生物&药学活性

物理化学性质&存储条件

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