Vandetanib trifluoroacetate |CAS:338992-53-3 Probechem Biochemicals

Chemical Structure : Vandetanib trifluoroacetate

CAS No.: 338992-53-3

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Vandetanib trifluoroacetate (ZD6474 trifluoroacetate;ZD-6474 trifluoroacetate;ZD 6474 trifluoroacetate)

货号: PC-42497Not For Human Use, Lab Use Only.

A potent and selective VEGFR2 (KDR) inhibitor with IC50 of 40 nM.

规格	价格	库存	数量
100 mg	￥1440	In stock
200 mg	￥2240	In stock

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生物&药学活性

A potent and selective VEGFR2 (KDR) inhibitor with IC50 of 40 nM; shows weak inhibition for VEGFR3 and EGFR (IC50 is 100 nM and 500 nM respectively); displays excellent selectivity over erbB2, MEK, CDK-2, Tie-2, IGFR-1R, PDK, PDGFRβ, and Akt (IC50=1.1-100 uM); has excellent solubility and good oral bioavailability.

Thyroid Cancer

Approved

物理化学性质&存储条件

分子量	589.3773
分子式	C24H25BrF4N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-, 2,2,2-trifluoroacetate (1:1)

参考文献

1. Hennequin LF, et al. J Med Chem. 2002 Mar 14;45(6):1300-12.

2. Wedge SR, et al. Cancer Res. 2002 Aug 15;62(16):4645-55.

3. Carlomagno F, et al. Cancer Res. 2002 Dec 15;62(24):7284-90.

Vandetanib trifluoroacetate (ZD6474 trifluoroacetate;ZD-6474 trifluoroacetate;ZD 6474 trifluoroacetate)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

Vandetanib trifluoroacetate (ZD6474 trifluoroacetate;ZD-6474 trifluoroacetate;ZD 6474 trifluoroacetate)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

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