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首页-小分子抑制剂&激动剂-Others-Other Targets-Vamorolone
Vamorolone

Chemical Structure : Vamorolone

CAS No.: 13209-41-1

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Vamorolone (VBP-15, VBP15)

货号: PC-35648Not For Human Use, Lab Use Only.

Vamorolone (VBP15) is a dissociative steroidal compound, reduces NF-κB-mediated cytokine expression in vitro, also reduecs glucocorticoid-mediated side-effects when compared to dexamethasone in vivo.

规格 价格 库存 数量
10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2480 In stock
100 mg ￥3980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Vamorolone (VBP15) is a dissociative steroidal compound, reduces NF-κB-mediated cytokine expression in vitro, also reduecs glucocorticoid-mediated side-effects when compared to dexamethasone in vivo.
Vamorolone reduces NF-κB pathway inflammatory cytokines in mouse primary DIPG cells, shows efficacy in inducing an anti-inflammatory response in animal models of asthma, multiple sclerosis, inflammatory bowel disease, and muscular dystrophies, and has shown fewer side effects.
Vamorolone increases physical activity of tumor bearing mice.

物理化学性质&存储条件

分子量 356.462
分子式 C22H28O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(8S,10S,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-3-one

参考文献

1. Wells E, et al. Oncotarget. 2017 Feb 7;8(6):9366-9374.

2. Conklin LS, et al. Pharmacol Res. 2018 Sep 13;136:140-150.

3. Hoffman EP, et al. Steroids. 2018 Jun;134:43-52.

4. Almeida LEF, et al. Sci Rep. 2018 Apr 17;8(1):6081.

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