Valproic acid (2-Propylpentanoic Acid) | HDAC inhibitor

Chemical Structure : Valproic acid

CAS No.: 99-66-1

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Valproic acid (VPA, 2-Propylpentanoic Acid, Dipropylacetic Acid)

货号: PC-42670Not For Human Use, Lab Use Only.

Valproic acid is a HDAC inhibitor that selectively inhibits the catalytic activity of class I HDACs, and induces proteasomal degradation of HDAC2.

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生物&药学活性

Valproic acid (2-Propylpentanoic Acid) is a HDAC inhibitor that selectively inhibits the catalytic activity of class I HDACs, and induces proteasomal degradation of HDAC2.
Valproic acid induces differentiation of carcinoma cells, transformed hematopoietic progenitor cells and leukemic blasts from AML patients.
Valproic acid reduces tumor growth and metastasis formation in animal model.

物理化学性质&存储条件

分子量	144.2114
分子式	C8H16O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in H2O
Chemical Name/SMILES	Pentanoic acid, 2-propyl-

参考文献

1. Krämer OH, et al. EMBO J. 2003 Jul 1;22(13):3411-20.

2. Göttlicher M, et al. EMBO J. 2001 Dec 17;20(24):6969-78.

3. Phiel CJ, et al. J Biol Chem. 2001 Sep 28;276(39):36734-41.

Valproic acid (VPA, 2-Propylpentanoic Acid, Dipropylacetic Acid)

生物&药学活性

物理化学性质&存储条件

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Valproic acid (VPA, 2-Propylpentanoic Acid, Dipropylacetic Acid)

生物&药学活性

物理化学性质&存储条件

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