Valecobulin | Tubulin inhibitor | Probechem Biochemicals

Chemical Structure : Valecobulin

CAS No.: 1188371-47-2

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Valecobulin (CKD-51, CKD516)

货号: PC-35472Not For Human Use, Lab Use Only.

CKD-516 (Valecobulin, CKD516) is a potent beta-tubulin polymerization inhibitor with marked antitumor activity both in vitro and in vivo.

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5880	In stock
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100 mg		Get quote

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生物&药学活性

CKD-516 (Valecobulin, CKD516) is a potent beta-tubulin polymerization inhibitor with marked antitumor activity both in vitro and in vivo.
CKD-516 demonstrates potent cytotoxicity against several cancer cells including P-gp overexpressing MDR positive cell line (HCT15), also induces cell cycle arrest at G(2)/M phase, which is associated with strong inhibition of tubulin polymerization.
CKD-516 shows antitumor efficacy against both murine tumors (CT26 and 3LL) and human xenogratfs (HCT116 and HCT15) in mice.

物理化学性质&存储条件

分子量	536.607
分子式	C26H28N6O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2-amino-3-methyl-N-{4-[3-(1H-1,2,4-triazol-1-yl)-4-(3,4,5-trimethoxybenzoyl)phenyl]-1,3-thiazol-2-yl}butanamide

参考文献

1. Lee J, et al. J Med Chem. 2010 Sep 9;53(17):6337-54.

2. Kim KW, et al. Invest New Drugs. 2013 Oct;31(5):1097-106.

3. Lee J, et al. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6327-30.

4. Kim YI, et al. Anticancer Res. 2014 Apr;34(4):1715-22.

Valecobulin (CKD-51, CKD516)

生物&药学活性

物理化学性质&存储条件

参考文献

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Valecobulin (CKD-51, CKD516)

生物&药学活性

物理化学性质&存储条件

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