Valdecoxib | COX-2 inhibitor | Probechem Biochemicals

Chemical Structure : Valdecoxib

CAS No.: 181695-72-7

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Valdecoxib (SC 65872, SC65872)

货号: PC-20874Not For Human Use, Lab Use Only.

Valdecoxib (SC 65872) is a potent and selective inhibitor of COX-2 with IC50 of 5 nM, shows no activity against COX-1.

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100 mg	￥1980	In stock
200 mg	￥2980	In stock
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5 g		Get quote

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生物&药学活性

Valdecoxib (SC 65872) is a potent and selective inhibitor of COX-2 with IC50 of 5 nM, shows no activity against COX-1.
Valdecoxib inhibits LPS-induced proliferation of endothelial cells and bFGF secretion in a dose-dependent manner.
Valdecoxib stimulates VEGF formation via HMEC-1 under inflammatory conditions. shows chronic antiinflammatory activity in the rat adjuvant arthritis model, with an ED50 of 0.032 mg/kg/day).
Valdecoxib (10 mg/kg, i.p.) significantly attenuates the behavioral and biochemical (oxidative damage) alterations in chronic-stressed mice.
Valdecoxib also selectively blocks rat TRPV2 channels in HEK293 and RBL-2H3 cells with IC50 of 9 and 11 uM, respectively, but not closely related TRPV1, TRPV3 or TRPV4 channels.

物理化学性质&存储条件

分子量	314.36
分子式	C16H14N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide

参考文献

1. Talley JJ, et al. J Med Chem. 2000 Mar 9;43(5):775-7.

2. Kumar A, et al. Neurosci Bull. 2010 Feb;26(1):17-27.

3. Bluhm Y, et al. Eur J Pharmacol. 2022 Jan 15;915:174702.

Valdecoxib (SC 65872, SC65872)

生物&药学活性

物理化学性质&存储条件

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Valdecoxib (SC 65872, SC65872)

生物&药学活性

物理化学性质&存储条件

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