Vacuolin-1 | PIKfyve inhibitor | Probechem Biochemicals

Chemical Structure : Vacuolin-1

CAS No.: 351986-85-1

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Vacuolin-1 (Vacuolin 1;Vacuolin1)

货号: PC-61038Not For Human Use, Lab Use Only.

Vacuolin-1 is a potent PIKfyve inhibitor that inhibits autophagy by impairing lysosomal maturation, potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

Vacuolin-1 is a potent PIKfyve inhibitor that inhibits autophagy by impairing lysosomal maturation, potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A.
Vacuolin-1 blocks the Ca(2+)-dependent exocytosis of lysosomes induced by ionomycin or plasma membrane wounding, without affecting the process of resealing, induces the formation of giant vacuoles.

物理化学性质&存储条件

分子量	577.4
分子式	C26H24IN7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-(2-(3-iodobenzylidene)hydrazinyl)-6-morpholino-N,N-diphenyl-1,3,5-triazin-2-amine

参考文献

1. Cerny J, et al. EMBO Rep. 2004 Sep;5(9):883-8.

2. Shaik GM, et al. Cell Signal. 2009 Aug;21(8):1337-45.

3. Lu Y, et al. Autophagy. 2014;10(11):1895-905.

4. Sano O, et al. FEBS Lett. 2016 Jun;590(11):1576-85.

Vacuolin-1 (Vacuolin 1;Vacuolin1)

生物&药学活性

物理化学性质&存储条件

参考文献

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Vacuolin-1 (Vacuolin 1;Vacuolin1)

生物&药学活性

物理化学性质&存储条件

参考文献

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