Vabicaserin (SCA-136)

Chemical Structure : Vabicaserin

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货号: PC-73309Not For Human Use, Lab Use Only.

Vabicaserin (SCA-136) is a potent, selective 5-HT2C receptor full agonist with EC50 of 8 nM, Emax 100%.

规格	价格	库存	数量
25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

Vabicaserin (SCA-136) is a potent, selective 5-HT2C receptor full agonist with EC50 of 8 nM, Emax 100%.
Vabicaserin displaced (125)I-(2,5-dimethoxy)phenylisopropylamine binding from human 5-HT(2C) receptor sites in CHO cell membranes with Ki of 3 nM, >50-fold selective over a number of serotonergic, noradrenergic, and dopaminergic receptors.
Vabicaserin is a potent and full agonist in stimulating 5-HT(2C) receptor-coupled calcium mobilization and exhibited 5-HT(2A) receptor antagonism and 5-HT(2B) antagonist or partial agonist activity in transfected cells, depending on the level of receptor expression.

物理化学性质&存储条件

分子量	264.797
分子式	C15H21ClN2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(12R,16S)-7,10-diazatetracyclo[8.6.1.05,17.012,16]heptadeca-1,3,5(17)-triene;hydrochloride

参考文献

1. Dunlop J, et al. J Pharmacol Exp Ther. 2011 Jun;337(3):673-80.

2. Ogino S, et al. Pharmacol Biochem Behav. 2013 Jul;108:8-15.