VX-765 (Belnacasan) | Caspase-1 inhibitor | Probechem Biochemicals

Chemical Structure : VX-765

CAS No.: 273404-37-8

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VX-765 (Belnacasan, VX765)

货号: PC-43391Not For Human Use, Lab Use Only.

VX-765 (Belnacasan) is an orally absorbed prodrug of VRT-043198, which is a potent and selective inhibitor of interleukin-converting enzyme/caspase-1 with Ki of 0.8 nM.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

VX-765 (Belnacasan) is an orally absorbed prodrug of VRT-043198, which is a potent and selective inhibitor of interleukin-converting enzyme/caspase-1 with Ki of 0.8 nM.
VRT-043198 exhibits 100- to 10,000-fold selectivity against other caspase-3 and -6 to -9, VX-765 is converted rapidly to VRT-043198 under the action of plasma and liver esterases.
VX-765 (Belnacasan) inhibits LPS-induced IL-1β production, reduces disease severity and the expression of inflammatory mediators in models of rheumatoid arthritis and skin inflammation.

物理化学性质&存储条件

分子量	508.995
分子式	C24H33ClN4O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 27 mg/mL
Chemical Name/SMILES	L-Prolinamide, N-(4-amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-

参考文献

1. Stack JH, et al. J Immunol. 2005 Aug 15;175(4):2630-4.

2. Wannamaker W, et al. J Pharmacol Exp Ther. 2007 May;321(2):509-16.

3. Bialer M, et al. Epilepsy Res. 2013 Jan;103(1):2-30.

4. Wang W, et al. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9587-92.

VX-765 (Belnacasan, VX765)

生物&药学活性

物理化学性质&存储条件

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VX-765 (Belnacasan, VX765)

生物&药学活性

物理化学性质&存储条件

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