VX-702 |CAS:745833-23-2 Probechem Biochemicals

Chemical Structure : VX-702

CAS No.: 745833-23-2

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VX-702 (VX702;VX 702)

货号: PC-42563Not For Human Use, Lab Use Only.

VX-702 is a potent, selective, second generation p38 MAPK inhibitor with IC50 of 4-20 nM for p38α.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

VX-702 is a potent, selective, second generation p38 MAPK inhibitor with IC50 of 4-20 nM for p38α.
VX-702 displays 14-fold higher potency against the p38α versus p38β.
VX-702 inhibits p38 activation induced by platelet agonists including thrombin, SFLLRN, AYPGKF, U46619 and collagen, without effect on collagen-mediated platelet aggregation.

物理化学性质&存储条件

分子量	404.3178
分子式	C19H12F4N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 42 mg/mL
Chemical Name/SMILES	3-Pyridinecarboxamide, 6-[(aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-

参考文献

1. Kuliopulos A, et al. Thromb Haemost. 2004 Dec;92(6):1387-93.

2. Damjanov N, et al. Arthritis Rheum. 2009 May;60(5):1232-41.

3. Ding C. Curr Opin Investig Drugs. 2006 Nov;7(11):1020-5.

4. Matsushita T, et al. Am J Pathol. 2017 Apr;187(4):841-850.

VX-702 (VX702;VX 702)

生物&药学活性

物理化学性质&存储条件

参考文献

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VX-702 (VX702;VX 702)

生物&药学活性

物理化学性质&存储条件

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