VX-148 |CAS:297730-05-3 Probechem Biochemicals

Chemical Structure : VX-148

加入收藏

VX-148 (VX148)

货号: PC-35012Not For Human Use, Lab Use Only.

VX-148 (VX148) is a potent, uncompetitive, orally bioavailable IMPDH inhibitor with Ki of 6 nM against IMPDH type II enzyme.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

VX-148 (VX148) is a potent, uncompetitive, orally bioavailable IMPDH inhibitor with Ki of 6 nM against IMPDH type II enzyme.
VX-148 is slightly more potent than VX-497 in inhibiting the proliferation of mitogen-stimulated primary human lymphocytes (IC50=80 nM).
VX-148 inhibits primary antibody response in mice with ED50 value of 38 mg/kg b.i.d, significantly prolongs skin graft survival at 100 mg/kg b.i.d.

物理化学性质&存储条件

分子量	435.48
分子式	C23H25N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-cyanobutan-2-yl ((S)-1-(3-(3-(4-cyano-3-methoxyphenyl)ureido)phenyl)ethyl)carbamate

参考文献

1. Jain J, et al. J Pharmacol Exp Ther. 2002 Sep;302(3):1272-7.

2. Dunkern T, et al. J Enzyme Inhib Med Chem. 2014 Jun;29(3):408-19.

VX-148 (VX148)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

VX-148 (VX148)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.