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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-ERK-VX-11e
VX-11e

Chemical Structure : VX-11e

CAS No.: 896720-20-0

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VX-11e (VX11e)

货号: PC-43855Not For Human Use, Lab Use Only.

VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK2 with Ki of <2 nM.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK2 with Ki of <2 nM.
VX-11e shows >200-fold selectivity over GSK3, Aurora A, CDK2, FLT3, etc.
VX-11e significantly inhibits CKAP2 overexpression-induced cell proliferation, migration and invasion in SiHa cells.

物理化学性质&存储条件

分子量 500.3523
分子式 C24H20Cl2FN5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Pyrrole-2-carboxamide, 4-[2-[(2-chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-

参考文献

1. Aronov AM, et al. J Med Chem. 2009 Oct 22;52(20):6362-8.

2. Krepler C, et al. Clin Cancer Res. 2016 Apr 1;22(7):1592-602.

3. Guo QS, et al. Sci Rep. 2017 May 18;7(1):2117.

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