VV261 | SFTSV/CCHFV/CHIKV inhibitor | Probechem Biochemicals

Chemical Structure : VV261

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VV261 (VV-261)

货号: PC-27841Not For Human Use, Lab Use Only.

VV261 is an oral 4'-Fluorouridine (4'-FU) double prodrug and severe fever with thrombocytopenia syndrome virus (SFTSV, Dabie bandavirus) inhibitor, potently inhibits Crimean-Congo hemorrhagic fever virus (CCHFV) infection with EC50 of 2.72 uM, targets viral RNA-dependent RNA polymerase (RdRp), also potently inhibits Chikungunya virus (CHIKV) with EC50 of 1.24 and 0.51 uM for CHIKV-Asian and CHIKV-ECSA respectively.

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100 mg		Get quote

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生物&药学活性

VV261 is an oral 4'-Fluorouridine (4'-FU) double prodrug and severe fever with thrombocytopenia syndrome virus (SFTSV, Dabie bandavirus) inhibitor, potently inhibits Crimean-Congo hemorrhagic fever virus (CCHFV) infection with EC50 of 2.72 uM, targets viral RNA-dependent RNA polymerase (RdRp), also potently inhibits Chikungunya virus (CHIKV) with EC50 of 1.24 and 0.51 uM for CHIKV-Asian and CHIKV-ECSA respectively.

物理化学性质&存储条件

分子量	607.59
分子式	C28H34FN3O11
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3S,4R,5R)-2-Fluoro-2-((isobutyryloxy)methyl)-5-(3-((nicotinoyloxy)methyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl bis(2-methylpropanoate)

参考文献

1. Cheng Y, et al. J Med Chem. 2025 May 8;68(9):9811-9826.

2. Wang X, et al. J Virol. 2025 Dec 23;99(12):e0158325.

3. Zhang Y, et al. Signal Transduct Target Ther. 2026 Feb 11;11(1):56.

VV261 (VV-261)

生物&药学活性

物理化学性质&存储条件

参考文献

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VV261 (VV-261)

生物&药学活性

物理化学性质&存储条件

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