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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-VUF11418
VUF11418

Chemical Structure : VUF11418

CAS No.: 1414376-85-4

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VUF11418 (VUF 11418)

货号: PC-38487Not For Human Use, Lab Use Only.

VUF11418 is a selective, nonpeptidomimetic agonist of CXCR3 with binding pKi vaule of 7.2, pEC50 value of 6.0 in [35S]GTPγS functional assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VUF11418 is a selective, nonpeptidomimetic agonist of CXCR3 with binding pKi vaule of 7.2, pEC50 value of 6.0 in [35S]GTPγS functional assays.
VUF11418 is a highly useful chemical tool for detailed assessment of CXCR3 activation as well as for studying downstream CXCR3 signaling.

物理化学性质&存储条件

分子量 599.339
分子式 C25H31I2N
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
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Solubility

10 mM in DMSO
Chemical Name/SMILES

2'-Iodo-N-[[(1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl]methyl]-N,N-dimethyl-[1,1'-biphenyl]-4-methanaminium iodide

参考文献

1. Wijtmans M, et al. J Med Chem. 2012 Dec 13;55(23):10572-83.

2. Scholten DJ, et al. Mol Pharmacol. 2015 Apr;87(4):639-48.

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