VUBI1 | SOS1 activator | Probechem Biochemicals

Chemical Structure : VUBI1

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VUBI1 (SOS1 activator 1)

货号: PC-38293Not For Human Use, Lab Use Only.

VUBI1 (SOS1 agonist 1) is a potent activator of SOS1 which modulates the KRAS pathway, binds directly to SOS1 (Kd=44 nM).

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生物&药学活性

VUBI1 (SOS1 agonist 1) is a potent activator of SOS1 which modulates the KRAS pathway, binds directly to SOS1 (Kd=44 nM).
VUBI1 increase nucleotide exchange on RAS in vitro at sub-micromolar concentration, rapidly enhances cellular RAS-GTP levels, and invokes biphasic signaling changes in phosphorylation of ERK 1/2 (Hela pERK ICW EC50=5.9 uM).

物理化学性质&存储条件

分子量	483.032
分子式	C26H32ClFN6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-chloro-1-(4-fluoro-3,5-dimethylbenzyl)-4-(4-methylpiperazin-1-yl)-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1H-benzo[d]imidazole

参考文献

1. Timothy R Hodges, et al. J Med Chem. 2018 Oct 11;61(19):8875-8894.

VUBI1 (SOS1 activator 1)

生物&药学活性

物理化学性质&存储条件

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VUBI1 (SOS1 activator 1)

生物&药学活性

物理化学性质&存储条件

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