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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-VU714
VU714

Chemical Structure : VU714

CAS No.: 441289-66-3

VU714 (VU-714;VU 714)

货号: PC-60573Not For Human Use, Lab Use Only.

VU714 is a potent inwardly rectifying K+ channel Kir7.1 inhibitor with IC50 of 5.6 uM in T1+ flux assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    VU714 is a potent inwardly rectifying K+ channel Kir7.1 inhibitor with IC50 of 5.6 uM in T1+ flux assays.
    VU714 inhibits other Kir channels with a rank order potency of Kir4.1 (IC50=13 µM) > Kir1.1 (IC50=16 µM) > Kir6.2/SUR1 (IC50=30 µM) > Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2 (IC50 > 30 µM).

    物理化学性质&存储条件

    分子量 366.889
    分子式 C22H23ClN2O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    8-Quinolinol, 5-chloro-7-[[4-(phenylmethyl)-1-piperidinyl]methyl]-

    参考文献

    1. Kharade SV, et al. Mol Pharmacol. 2017 Sep;92(3):338-346.

    2. Swale DR, et al. ACS Chem Neurosci. 2016 Jul 20;7(7):1013-23.

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