VU661013 |CAS:2131184-57-9 Probechem Biochemicals

Chemical Structure : VU661013

CAS No.: 2131184-57-9

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VU661013 (VU 661013;VU-661013)

货号: PC-35655Not For Human Use, Lab Use Only.

VU661013 (VU-661013) is a novel potent, selective MCL-1 inhibitor with Ki of 97 pM (human MCL-1) in TR-FRET assay, shows no significant inhibition on BCL-xL (Ki>40 uM) or BCL-2 (Ki=0.73 uM).

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5 mg	￥4580	In stock
10 mg	￥7580	In stock
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生物&药学活性

VU661013 (VU-661013) is a novel potent, selective MCL-1 inhibitor with Ki of 97 pM (human MCL-1) in TR-FRET assay, shows no significant inhibition on BCL-xL (Ki>40 uM) or BCL-2 (Ki=0.73 uM).
VU661013 de-stabilizes BIM/MCL-1 association, leads to apoptosis in AML.
VU661013 is active in venetoclax-resistant cells and patient derived xenografts.

物理化学性质&存储条件

分子量	712.672
分子式	C39H39Cl2N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(7-chloro-10-(3-(4-chloro-3,5-dimethylphenoxy)propyl)-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)-1-methyl-1H-indole-5-carboxylic acid

参考文献

1. Ramsey HE, et al. Cancer Discov. 2018 Sep 5. pii: CD-18-0140.

2. Zhao B, et al. Biochemistry. 2018 Aug 14;57(32):4952-4958.

VU661013 (VU 661013;VU-661013)

生物&药学活性

物理化学性质&存储条件

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VU661013 (VU 661013;VU-661013)

生物&药学活性

物理化学性质&存储条件

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